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Dact1tm1.2Bnrc
Targeted Allele Detail
Nomenclature
Symbol: Dact1tm1.2Bnrc
Name: dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1.2, Benjamin N R Cheyette
MGI ID: MGI:4442991
Synonyms: Dact1flox
Gene: Dact1  Location: Chr12:71356658-71366881 bp, + strand  Genetic Position: Chr12, 29.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159217
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a frt-flanked neomycin resistance (neo) cassette, followed by a loxP site, upstream of exon 2, and a second loxP site downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:152701, J:159217)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dact1 Mutation:  13 strains or lines available
References
Original:  J:159217 Okerlund ND, et al., Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24;30(12):4362-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory