Klrb1c^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Klrb1c^m1Btlr
• Name: killer cell lectin-like receptor subfamily B member 1C; mutation 1, Bruce Beutler
• MGI ID: MGI:4442848
• Synonyms: Unnatural
• Gene: Klrb1c Location: Chr6:128755448-128765514 bp, - strand Genetic Position: Chr6, 63.09 cM
• Alliance: Klrb1c^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation comprises an A to G transition at position 398 of the mRNA sequence (Genbank accession NM_008527), in the fourth of the gene's 6 exons, resulting in replacement of aspartic acid by glycine at amino acid position 100 (D100Q) of the natural killer receptor protein 1C (NKR-P1C, also known as NK1.1). This protein, which normally is present on the surface of natural killer (NK) cells and natural killer T (NKT) lymphocytes, is absent in homozygous mutant mice and present at ~50% of normal levles in heterozygous mutants. (J:159356)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klrb1c Mutation: 22 strains or lines available

References

• Original: J:159356 Siggs OM, et al., Unnatural is an allele of Klrb1c, which encodes NKR-P1C/NK1.1. MGI Direct Data Submission. 2010
• All: 1 reference(s)