Fbln5^tm1.1Hiya
Targeted Allele Detail

Summary

• Symbol: Fbln5^tm1.1Hiya
• Name: fibulin 5; targeted mutation 1.1, Hiromi Yanagisawa
• MGI ID: MGI:4442490
• Synonyms: Flbn5^RGE
• Gene: Fbln5 Location: Chr12:101712824-101785314 bp, - strand Genetic Position: Chr12, 51.29 cM, cytoband F1
• Alliance: Fbln5^tm1.1Hiya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159246
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Aspartic acid codon 56 (GAC) the integrin-binding RGD sequence in exon 4 was changed to glutamic acid (GAG) (p.D56E). The protein product is predicted to be deficient in integrin-binding. A loxP flanked neomycin resistance gene cassette used for selection was removed by Cre-mediated recombination. (J:159246, J:173933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbln5 Mutation: 35 strains or lines available

References

• Original: J:159246 Schluterman MK, et al., Loss of fibulin-5 binding to {beta}1 integrins inhibits tumor growth by increasing the level of ROS. Dis Model Mech. 2010 May-Jun;3(5-6):333-42
• All: 4 reference(s)