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Targeted Allele Detail
Symbol: Xirp1tm1Dofr
Name: xin actin-binding repeat containing 1; targeted mutation 1, Dieter O Furst
MGI ID: MGI:4442410
Synonyms: XinABC-
Gene: Xirp1  Location: Chr9:120013755-120023598 bp, - strand  Genetic Position: Chr9, 71.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:159352
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA vector composed of an IRES element, beta-gal, and a neomycin selection cassette was inserted between the XhoI restriction site near the 5' end of exon 2 and the BamHI site near the 3' end of the same exon. Immunohistochemical analysis confirmed that all three isoforms are not expressed. (J:159352)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xirp1 Mutation:  1 strain or line available
Original:  J:159352 Otten J, et al., Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res. 2010 Mar 1;85(4):739-50
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory