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Ptentm1.1Gle
Targeted Allele Detail
Nomenclature
Symbol: Ptentm1.1Gle
Name: phosphatase and tensin homolog; targeted mutation 1.1, Gustavo Leone
MGI ID: MGI:4442330
Synonyms: PtenC124R
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158751
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe codon TGT for Cysteine124 within exon 5, was mutated to CGT for Arginine. In addition a floxed neo cassette was introduced within intron 4. The selection cassette was removed by cre mediated recombination. (J:158751)
Generation, targeting, and verification of point mutations of Pten alleles.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  50 strains or lines available
References
Original:  J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory