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Ptentm1.2Mwst
Targeted Allele Detail
Nomenclature
Symbol: Ptentm1.2Mwst
Name: phosphatase and tensin homolog; targeted mutation 1.2, Michael Weinstein
MGI ID: MGI:4442327
Synonyms: Ptendelta4-5
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158751
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and a floxed neo allele was inserted downstream of exon 5. Cre mediated recombination removed the neo cassette and exons 4 and 5. (J:158751)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  50 strains or lines available
References
Original:  J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory