About   Help   FAQ
Targeted Allele Detail
Symbol: Dlg3tm1a(EUCOMM)Wtsi
Name: discs large MAGUK scaffold protein 3; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4441739
Gene: Dlg3  Location: ChrX:100767722-100818410 bp, + strand  Genetic Position: ChrX, 43.72 cM, cytoband C2
Mutant Cell Lines:  EPD0525_1_A08, EPD0525_1_B05, EPD0525_1_B06, EPD0525_1_B07, EPD0525_1_C05, EPD0525_1_C06, EPD0525_1_C07, EPD0525_1_C08, EPD0525_1_D05, EPD0525_1_D08, EPD0525_1_E05, EPD0525_1_E07, EPD0525_1_E08, EPD0525_1_F06, EPD0525_1_F07, EPD0525_1_F08, EPD0525_1_G05, EPD0525_1_G07, EPD0525_1_H06, EPD0525_1_H07, EPD0525_1_H08
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt1
Mutation detailsThe L1L2_gt1 cassette was inserted at position 100796252 of Chromosome X upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 100797023. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Dlg3 Mutation:  25 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory