Terf2ip^tm1.1Tdl
Targeted Allele Detail

Summary

• Symbol: Terf2ip^tm1.1Tdl
• Name: telomeric repeat binding factor 2, interacting protein; targeted mutation 1.1, Titia de Lange
• MGI ID: MGI:4441595
• Synonyms: Rap1^F
• Gene: Terf2ip Location: Chr8:112738030-112747160 bp, + strand Genetic Position: Chr8, 58.29 cM
• Alliance: Terf2ip^tm1.1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158884
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:158884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Terf2ip Mutation: 31 strains or lines available

References

• Original: J:158884 Sfeir A, et al., Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science. 2010 Mar 26;327(5973):1657-61
• All: 4 reference(s)