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Targeted Allele Detail
Symbol: Fntbtm1.1Mbrg
Name: farnesyltransferase, CAAX box, beta; targeted mutation 1.1, Martin O Bergo
MGI ID: MGI:4441481
Synonyms: Fntbfl, Fntbfldeltaneo
Gene: Fntb  Location: Chr12:76837400-76921412 bp, + strand  Genetic Position: Chr12, 33.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:158937
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsTwo loxP sites were inserted 1kb upstream and 1kb downstream of exon 1, followed by a floxed neo cassette. The neo cassette has been removed by cre mediated recombination. (J:158937)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fntb Mutation:  193 strains or lines available
Original:  J:158937 Liu M, et al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6471-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory