Tg(Mt1-TTR)MRA434Hsas
Transgene Detail

Summary

• Symbol: Tg(Mt1-TTR)MRA434Hsas
• Name: transgene insertion MRA434, Hiroyuki Sasaki
• MGI ID: MGI:4441477
• Transgene: Tg(Mt1-TTR)MRA434Hsas Location: unknown Genetic Position: Chr11, cytoband A5
• Alliance: Tg(Mt1-TTR)MRA434Hsas page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 x BALB/c

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-TTR)MRA434Hsas expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TTR (7276)

  Ttr	(MGI:98865)

• Tg(Mt1-TTR)MRA434Hsas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mt1 (MGI:97171)

• Mutation details: Human TTR was placed under the control of the mouse Mt1 promoter. Ten positive founders were established. The serum TTR concentration was 1.40 mg/dl. (J:159166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:159166 Sasaki H, et al., Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy. Biochem Biophys Res Commun. 1986 Sep 14;139(2):794-9
• All: 3 reference(s)