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Targeted Allele Detail
Symbol: Ces1dtm1Rile
Name: carboxylesterase 1D; targeted mutation 1, Richard Lehner
MGI ID: MGI:4440967
Synonyms: Tgh-
Gene: Ces1d  Location: Chr8:93166068-93197838 bp, - strand  Genetic Position: Chr8, 45.05 cM, cytoband C5
Germline Transmission:  Earliest citation of germline transmission: J:158743
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5, which encodes the catalytic serine at position 221, was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158743)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ces1d Mutation:  19 strains or lines available
Original:  J:158743 Wei E, et al., Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure. Cell Metab. 2010 Mar 3;11(3):183-93
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory