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Ces1dtm1Rile
Targeted Allele Detail
Nomenclature
Symbol: Ces1dtm1Rile
Name: carboxylesterase 1D; targeted mutation 1, Richard Lehner
MGI ID: MGI:4440967
Synonyms: Tgh-
Gene: Ces1d  Location: Chr8:93166068-93197838 bp, - strand  Genetic Position: Chr8, 45.05 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158743
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5, which encodes the catalytic serine at position 221, was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158743)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ces1d Mutation:  13 strains or lines available
References
Original:  J:158743 Wei E, et al., Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure. Cell Metab. 2010 Mar 3;11(3):183-93
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory