About   Help   FAQ
Targeted Allele Detail
Symbol: Rab25tm1Jrgo
Name: RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring
MGI ID: MGI:4440861
Synonyms: Rab25-
Gene: Rab25  Location: Chr3:88542029-88548300 bp, - strand  Genetic Position: Chr3, 38.87 cM, cytoband E3-F1
Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:158733
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe neomycin resistance gene along with 3 tandem in-frame stop codons was inserted into the second exon. Western blot and immunostaining indicated a lack of protein expression in the intestines of homozygous mice. (J:158733)
Construction of Rab25tm1Jrgo allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rab25 Mutation:  4 strains or lines available
Original:  J:158733 Nam KT, et al., Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest. 2010 Mar;120(3):840-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory