Plch2^tm1Kfu
Targeted Allele Detail

Summary

• Symbol: Plch2^tm1Kfu
• Name: phospholipase C, eta 2; targeted mutation 1, Kiyoko Fukami
• MGI ID: MGI:4440833
• Synonyms: plch2^lacZ
• Gene: Plch2 Location: Chr4:155067572-155141241 bp, - strand Genetic Position: Chr4, 86.13 cM
• Alliance: Plch2^tm1Kfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158427
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Genomic sequence spanning part of exon 1 through exon 3 was replaced with (from 5' to 3'): a loxP site, lacZ gene, frt-flanked neo cassette, loxP site, and polyadenylation site. The absence of full-length protein expression was confirmed by western blot analysis on brain extracts. Small amounts of a truncated peptide is detected. (J:158427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plch2 Mutation: 93 strains or lines available

References

• Original: J:158427 Kanemaru K, et al., Phospholipase C-eta2 is highly expressed in the habenula and retina. Gene Expr Patterns. 2010 February - March;10(2-3):119-126
• All: 1 reference(s)