Ret^tm1.2Pern
Targeted Allele Detail

Summary

• Symbol: Ret^tm1.2Pern
• Name: ret proto-oncogene; targeted mutation 1.2, Patrik Ernfors
• MGI ID: MGI:4440476
• Synonyms: Ret^delta, RetKO
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1.2Pern page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131770
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying the Ret^tm1.1Pern allele were crossed to Tg(Pgk1-cre)1Lni transgenic mice to removed the floxed region of Ret. Heterozygous kinase-dead animals are viable. (J:131770)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:131770 Baudet C, et al., Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci. 2008 Jan 23;28(4):963-75
• All: 1 reference(s)