Nkx6-2^tm2(cre)Ercs
Targeted Allele Detail

Summary

• Symbol: Nkx6-2^tm2(cre)Ercs
• Name: NK6 homeobox 2; targeted mutation 2, Johan Ericson
• MGI ID: MGI:4440471
• Synonyms: Nkx6.2^cre, Nkx6.2-Cre
• Gene: Nkx6-2 Location: Chr7:139159292-139162713 bp, - strand Genetic Position: Chr7, 84.57 cM
• Alliance: Nkx6-2^tm2(cre)Ercs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131770
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Nkx6-2^tm2(cre)Ercs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx6-2 (MGI:1352738)

• Mutation details: The targeting vector used to generate the Nkx6-2^tm1Ercs allele was modified by replacing the lacZ/PGKneo cassette with a cre/PGKneo cassette. The same strategy as described in J:71607 was followed to generate this Nkx6-2 mutant allele using the modified targeting vector. (J:131770)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx6-2 (mouse) Summary of all recombinase alleles driven by Nkx6-2. Alliance mouse Nkx6-2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx6-2 Mutation: 16 strains or lines available

References

• Original: J:131770 Baudet C, et al., Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci. 2008 Jan 23;28(4):963-75
• All: 5 reference(s)