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Targeted Allele Detail
Symbol: Dcktm1.1Radu
Name: deoxycytidine kinase; targeted mutation 1.1, Caius G Radu
MGI ID: MGI:4440453
Gene: Dck  Location: Chr5:88764996-88783281 bp, + strand  Genetic Position: Chr5, 43.96 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:158373
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was floxed and an FRT flanked neo cassette was inserted within intron 3 by homologous recombination. Exon 3 is deleted by cre mediated recombination which eliminated the catalytic domain and also caused a frameshift mutation and early termination of the protein. Loss of function was confirmed by in vitro kinase assay as well as PET and CT imaging with labeled probes. (J:158373)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dck Mutation:  15 strains or lines available
Original:  J:158373 Toy G, et al., Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5551-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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