Huwe1^tm1.1Alas
Targeted Allele Detail

Summary

• Symbol: Huwe1^tm1.1Alas
• Name: HECT, UBA and WWE domain containing 1; targeted mutation 1.1, Anna Lasorella
• MGI ID: MGI:4439484
• Synonyms: Huwe1^deltaHECT
• Gene: Huwe1 Location: ChrX:150583803-150718413 bp, + strand Genetic Position: ChrX, 68.46 cM

Mutation origin

• Germline Transmission: Unknown
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A transient expression of cre in Huwe1^tm1Alas ES cells results in the removal of the NeoR cassette and 197 amino acids corresponding to exons 80-82 of Huwe1 encoding most of the HECT domain of Huwe1. (J:145660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Huwe1 Mutation: 62 strains or lines available

References

• Original: J:145660 Zhao X, et al., The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008 Jun;10(6):643-53
• All: 1 reference(s)