Tg(tetO-Cd74/MCC)#Doi
Transgene Detail

Summary

• Symbol: Tg(tetO-Cd74/MCC)#Doi
• Name: transgene insertion #, Christophe Benoist and Diane Mathis
• MGI ID: MGI:4439134
• Synonyms: TIM
• Transgene: Tg(tetO-Cd74/MCC)#Doi Location: unknown
• Alliance: Tg(tetO-Cd74/MCC)#Doi page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Seven tetO sequences were combined with the CMV minimal promoter to drive expression, when induced by doxycycline, of a construct composed of the Cd74 cDNA and a segment of moth cytochrome c DNA encoding amino acid residues 93 to 103 replacing the CLIP region of Cd74, encoding amino acid residues 88 to 98. (J:94535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94535 van Santen HM, et al., Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med. 2004 Nov 15;200(10):1221-30
• All: 5 reference(s)