Tg(TG-TSHR)50.6Smcl
Transgene Detail

Summary

• Symbol: Tg(TG-TSHR)50.6Smcl
• Name: transgene insertion 50.6, Sandra M McLachlan
• MGI ID: MGI:4438958
• Transgene: Tg(TG-TSHR)50.6Smcl Location: unknown
• Alliance: Tg(TG-TSHR)50.6Smcl page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TG-TSHR)50.6Smcl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TSHR (7253)

  Tshr	(MGI:98849)

• Mutation details: This transgene expresses the human TSHR alpha-subunit cDNA (amino acid residues 1-289) with a 6-histidine tag under the control of the bovine thyroglobulin promoter. Human TSHR alpha-subunit expression, analyzed by RT-PCR, is detected in thyroid tissue from transgenic mice. Lines 51.9 and 60.6 were also generated. (J:118100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:118100 Pichurin PN, et al., Targeted expression of the human thyrotropin receptor A-subunit to the mouse thyroid: insight into overcoming the lack of response to A-subunit adenovirus immunization. J Immunol. 2006 Jan 1;176(1):668-76
• All: 3 reference(s)