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Srrtm1.2Jtc
Targeted Allele Detail
Summary
Symbol: Srrtm1.2Jtc
Name: serine racemase; targeted mutation 1.2, Joseph T Coyle
MGI ID: MGI:4438917
Synonyms: SR-
Gene: Srr  Location: Chr11:74797185-74816774 bp, - strand  Genetic Position: Chr11, 45.76 cM, cytoband B4
Alliance: Srrtm1.2Jtc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158266
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin phosphotransferase cassette was inserted with intron 1 and another loxP sequence 5' to exon 1 by homologous recombination. The selection cassette and exon 1 were removed by cre mediated recombination. Absence of protein was confirmed by western blot of whole brain extracts. (J:158266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srr Mutation:  32 strains or lines available
References
Original:  J:158266 Basu AC, et al., Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry. 2009 Jul;14(7):719-27
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory