Creb3l1^tm1Kaim
Targeted Allele Detail

Summary

• Symbol: Creb3l1^tm1Kaim
• Name: cAMP responsive element binding protein 3-like 1; targeted mutation 1, Kazunori Imaizumi
• MGI ID: MGI:4438907
• Synonyms: OASIS^-
• Gene: Creb3l1 Location: Chr2:91812673-91854515 bp, - strand Genetic Position: Chr2, 50.63 cM, cytoband E1
• Alliance: Creb3l1^tm1Kaim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158242
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a STOP codon and neo cassette. The absence of protein expression was confirmed by western blot analysis on primary osteoblast extracts. (J:158242)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb3l1 Mutation: 54 strains or lines available

References

• Original: J:158242 Murakami T, et al., Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol. 2009 Oct;11(10):1205-11
• All: 11 reference(s)