Tg(Thy1-CST3*)68Jckr
Transgene Detail

Summary

• Symbol: Tg(Thy1-CST3*)68Jckr
• Name: transgene insertion 68, Mathias Jucker
• MGI ID: MGI:4438904
• Synonyms: Cys68
• Transgene: Tg(Thy1-CST3*)68Jckr Location: unknown
• Alliance: Tg(Thy1-CST3*)68Jckr page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-CST3*)68Jckr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CST3 (1471)

  Cst3	(MGI:102519)

• Mutation details: A human Cystatin C cDNA containing a mutation in the codon for amino acid residue 68 causing a leucine to glutamine change was placed under the control of a murine Thy-1 promoter. This is a high expressing line. A lower expressing line 28 was also created. (J:130211)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130211 Kaeser SA, et al., Cystatin C modulates cerebral beta-amyloidosis. Nat Genet. 2007 Dec;39(12):1437-9
• All: 1 reference(s)