Chrm3^tm2.1Jwe
Targeted Allele Detail

Summary

• Symbol: Chrm3^tm2.1Jwe
• Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 2.1, Jurgen Wess
• MGI ID: MGI:4438742
• Synonyms: M3^fl
• Gene: Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
• Alliance: Chrm3^tm2.1Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158245
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Cre mediated recombination removed the neo cassette leaving the coding region floxed. (J:158245)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm3 Mutation: 50 strains or lines available

References

• Original: J:158245 Li JH, et al., Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice. Diabetes. 2009 Dec;58(12):2776-87
• All: 2 reference(s)