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Targeted Allele Detail
Symbol: Dbn1tm1.1Shira
Name: drebrin 1; targeted mutation 1.1, Tomoaki Shirao
MGI ID: MGI:4438710
Synonyms: DAKO
Gene: Dbn1  Location: Chr13:55473429-55488111 bp, - strand  Genetic Position: Chr13, 30.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:158208
Parent Cell Line:  MS12 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neo cassette was inserted within exon 11a and exon 11a was floxed by homologous recombination. The neo cassette and exon 11a were removed by cre mediated recombination. Western blotting confirmed the presence of the E form instead of the A form in cerebral cortices lysates of adult. (J:158208)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dbn1 Mutation:  26 strains or lines available
Original:  J:158208 Kojima N, et al., Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 2010 Jan 13;165(1):138-50
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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