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Targeted Allele Detail
Symbol: Slc20a1tm1.2Lbek
Name: solute carrier family 20, member 1; targeted mutation 1.2, Laurent Beck
MGI ID: MGI:4438614
Synonyms: PiT1delta5
Gene: Slc20a1  Location: Chr2:129198764-129211616 bp, + strand  Genetic Position: Chr2, 62.79 cM
Defective liver development and anemia in Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek embryos

Show the 7 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:157997
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT flanked neo cassette was inserted in intron 5, and exon 5 was flanked 5' and 3' with loxP sites 532 bp upstream and 934 bp downstream. The selection cassette and exon 5 were removed by cre mediated recombination. Absence of transcript was confirmed by Northern blot analysis of E12.5 whole embryos. (J:157997)
Generation of the Slc20a1tm1Lbek, Slc20a1tm1.1Lbek and Slc20a1tm1.2Lbek alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc20a1 Mutation:  21 strains or lines available
Original:  J:157997 Beck L, et al., The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory