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Bclaf1tm1Raz
Targeted Allele Detail
Nomenclature
Symbol: Bclaf1tm1Raz
Name: BCL2-associated transcription factor 1; targeted mutation 1, Razqallah Hakem
MGI ID: MGI:4438380
Gene: Bclaf1  Location: Chr10:20310512-20342644 bp, + strand  Genetic Position: Chr10, 9.75 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158087
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a neo cassette and a STOP codon was inserted into exon 3. The absence of of protein expression was confirmed by western blot analysis on fibroblast extracts. (J:158087)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bclaf1 Mutation:  24 strains or lines available
References
Original:  J:158087 McPherson JP, et al., Essential role for Bclaf1 in lung development and immune system function. Cell Death Differ. 2009 Feb;16(2):331-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory