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Lgr6tm2.1(cre/ERT2)Cle
Targeted Allele Detail
Nomenclature
Symbol: Lgr6tm2.1(cre/ERT2)Cle
Name: leucine-rich repeat-containing G protein-coupled receptor 6; targeted mutation 2.1, Hans Clevers
MGI ID: MGI:4438349
Synonyms: Lgr6-EGFP, Lgr6-EGFP-Ires-CreERT2
Gene: Lgr6  Location: Chr1:134983301-135105276 bp, - strand  Genetic Position: Chr1, 58.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157895
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn EGFP-IRES-CreERT2 cassette was inserted at the transcriptional start site along with a loxP-flanked neomycin cassette by homologous recombination. The neomycin gene was then removed by cre mediated recombination. EGFP expression is driven by the endogenous promoter. Cre expression is induced by tamoxifen treatment. (J:157895)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lgr6     Summary of all recombinase alleles driven by Lgr6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lgr6 Mutation:  60 strains or lines available
References
Original:  J:157895 Snippert HJ, et al., Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory