Tg(tetO-Akt1*)K8Lbjn
Transgene Detail

Summary

• Symbol: Tg(tetO-Akt1*)K8Lbjn
• Name: transgene insertion K8, Laura E Benjamin
• MGI ID: MGI:4437713
• Synonyms: TET:myrAkt
• Transgene: Tg(tetO-Akt1*)K8Lbjn Location: unknown
• Alliance: Tg(tetO-Akt1*)K8Lbjn page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A dominant active form of Akt1 with a c-Src myristoylation sequence and a hemagglutinin tag added to the N-terminus was inserted behind a tetracycline-responsive promoter (tetO). Two lines were tested and displayed similar performance. Line K8 was studied further. (J:95750)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-Akt1*)K8Lbjn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:95750 Sun JF, et al., Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):128-33
• All: 10 reference(s)