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Targeted Allele Detail
Symbol: Hprttm1(tetO-lacZ)Frje
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1, Frederic Jaisser
MGI ID: MGI:4437604
Synonyms: GR-tetO-LacZ
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Germline Transmission:  Earliest citation of germline transmission: J:157969
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129 and C57BL/6
Allele Type:    Targeted (Inducible, Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA transgene containing a bidirectional tetracycline promoter (tetO) driving expression of human GR1 (5' of tetO) and lacZ (3' of tetO) was inserted into the locus by homologous recombination. Selection was achieved by restoring the locus that is defective in the ES cells used to generate this allele. No GR1 expression was detected following activation of tetO where as lacZ expression is detected. (J:157969)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  31 strains or lines available
ES cell line = BPES11 (carries Hprtb-m3). This cell line was established from Hprt mutant mice on a highly mixed C57BL/6 and 129 background that had been derived from ES cell line BK4 (129P2/OlaHsd).
Original:  J:157969 Palais G, et al., Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics. 2009 Apr 10;37(2):140-6
All:  1 reference(s)

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MGI 6.12
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