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Trdntm1.2Isma
Targeted Allele Detail
Nomenclature
Symbol: Trdntm1.2Isma
Name: triadin; targeted mutation 1.2, Isabelle Marty
MGI ID: MGI:4437311
Gene: Trdn  Location: Chr10:33083483-33476709 bp, + strand  Genetic Position: Chr10, 18.37 cM, cytoband B1
Abnormal skeletal muscle fiber triad morphology in Trdntm1.2Isma/Trdntm1.2Isma mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157794
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exon 1. The absence of all protein isoforms was confirmed by western blot analysis on muscle and heart extracts. (J:157794)
Generation of the Trdntm1.1Isma and Trdntm1.2Isma alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trdn Mutation:  10 strains or lines available
References
Original:  J:157794 Oddoux S, et al., Triadin deletion induces impaired skeletal muscle function. J Biol Chem. 2009 Dec 11;284(50):34918-29
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory