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Targeted Allele Detail
Symbol: Trdntm1.2Isma
Name: triadin; targeted mutation 1.2, Isabelle Marty
MGI ID: MGI:4437311
Gene: Trdn  Location: Chr10:33083483-33476709 bp, + strand  Genetic Position: Chr10, 18.37 cM, cytoband B1
Abnormal skeletal muscle fiber triad morphology in Trdntm1.2Isma/Trdntm1.2Isma mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:157794
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre mediated recombination removed exon 1. The absence of all protein isoforms was confirmed by western blot analysis on muscle and heart extracts. (J:157794)
Generation of the Trdntm1.1Isma and Trdntm1.2Isma alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trdn Mutation:  40 strains or lines available
Original:  J:157794 Oddoux S, et al., Triadin deletion induces impaired skeletal muscle function. J Biol Chem. 2009 Dec 11;284(50):34918-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory