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Dhx58tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Dhx58tm1Aki
Name: DEXH (Asp-Glu-X-His) box polypeptide 58; targeted mutation 1, Shizuo Akira
MGI ID: MGI:4437255
Gene: Dhx58  Location: Chr11:100694884-100704271 bp, - strand  Genetic Position: Chr11, 63.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156867
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-5 were replaced by a neo cassette. Northern blot analysis failed to detect mRNA in homozygous MEFs. (J:156867)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dhx58 Mutation:  16 strains or lines available
References
Original:  J:156867 Satoh T, et al., LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory