Bhlhe41^tm1.1Cdon
Targeted Allele Detail

Summary

• Symbol: Bhlhe41^tm1.1Cdon
• Name: basic helix-loop-helix family, member e41; targeted mutation 1.1, Chen Dong
• MGI ID: MGI:4437241
• Synonyms: Dec2^-
• Gene: Bhlhe41 Location: Chr6:145803969-145811146 bp, - strand Genetic Position: Chr6, 77.7 cM, cytoband G2-G3
• Alliance: Bhlhe41^tm1.1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157740
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt and loxP flanked neo cassette was inserted upsteam of exon 1 and an additional loxP site was inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. Reduced protein expression was confirmed by western blot analysis on splenocyte extracts. (J:157740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bhlhe41 Mutation: 12 strains or lines available

References

• Original: J:157740 Yang XO, et al., Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009 Dec;10(12):1260-6
• All: 1 reference(s)