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Bhlhe41tm1.1Cdon
Targeted Allele Detail
Nomenclature
Symbol: Bhlhe41tm1.1Cdon
Name: basic helix-loop-helix family, member e41; targeted mutation 1.1, Chen Dong
MGI ID: MGI:4437241
Synonyms: Dec2-
Gene: Bhlhe41  Location: Chr6:145858243-145865558 bp, - strand  Genetic Position: Chr6, 77.7 cM, cytoband G2-G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157740
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn frt and loxP flanked neo cassette was inserted upsteam of exon 1 and an additional loxP site was inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. Reduced protein expression was confirmed by western blot analysis on splenocyte extracts. (J:157740)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe41 Mutation:  5 strains or lines available
References
Original:  J:157740 Yang XO, et al., Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009 Dec;10(12):1260-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory