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Setd2tm1Zhch
Targeted Allele Detail
Nomenclature
Symbol: Setd2tm1Zhch
Name: SET domain containing 2; targeted mutation 1, Zhu Chen
MGI ID: MGI:4437211
Synonyms: Hypb-
Gene: Setd2  Location: Chr9:110532597-110618633 bp, + strand  Genetic Position: Chr9, 60.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157570
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence spanning most of exon 4 through part of exon 5 was replaced with a neo cassette disrupting the SET domain. (J:157570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Setd2 Mutation:  59 strains or lines available
References
Original:  J:157570 Hu M, et al., Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory