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Targeted Allele Detail
Symbol: Nr1h2tm1Dgen
Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, Deltagen
MGI ID: MGI:4437128
Synonyms: Lxrbeta-
Gene: Nr1h2  Location: Chr7:44549616-44553951 bp, - strand  Genetic Position: Chr7, 28.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:157551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129/Sv x C57BL/6)F1
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced part of the coding sequences for the gene. Mice were created from line T684. (J:157551)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h2 Mutation:  14 strains or lines available
Original:  J:157551 Li N, et al., LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory