About   Help   FAQ
Nr1h2tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Nr1h2tm1Dgen
Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, Deltagen
MGI ID: MGI:4437128
Synonyms: Lxrbeta-
Gene: Nr1h2  Location: Chr7:44549616-44553951 bp, - strand  Genetic Position: Chr7, 28.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129/Sv x C57BL/6)F1
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of the coding sequences for the gene. Mice were created from line T684. (J:157551)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h2 Mutation:  12 strains or lines available
References
Original:  J:157551 Li N, et al., LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory