About   Help   FAQ
Targeted Allele Detail
Symbol: Adam24tm1Pmkf
Name: a disintegrin and metallopeptidase domain 24 (testase 1); targeted mutation 1, Paul Primakoff
MGI ID: MGI:4437125
Gene: Adam24  Location: Chr8:40675077-40682199 bp, + strand  Genetic Position: Chr8, 23.89 cM
In vivo polyspermy with Adam24tm1Pmkf/Adam24tm1Pmkf male mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:157046
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 576 amino acids have been eliminated by the insertion of a neomycin cassette by homologous recombination. The 88 KDa protein was absent on a western blot of mature sperm. (J:157046)
Generation of the Adam24tm1Pmkf allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam24 Mutation:  16 strains or lines available
Original:  J:157046 Zhu GZ, et al., Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009 Nov;76(11):1106-14
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory