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Targeted Allele Detail
Symbol: Adam24tm1Pmkf
Name: a disintegrin and metallopeptidase domain 24 (testase 1); targeted mutation 1, Paul Primakoff
MGI ID: MGI:4437125
Gene: Adam24  Location: Chr8:40675077-40682199 bp, + strand  Genetic Position: Chr8, 23.89 cM
In vivo polyspermy with Adam24tm1Pmkf/Adam24tm1Pmkf male mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:157046
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 576 amino acids have been eliminated by the insertion of a neomycin cassette by homologous recombination. The 88 KDa protein was absent on a western blot of mature sperm. (J:157046)
Generation of the Adam24tm1Pmkf allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam24 Mutation:  17 strains or lines available
Original:  J:157046 Zhu GZ, et al., Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009 Nov;76(11):1106-14
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.13
The Jackson Laboratory