Sertad1^tm1Srn
Targeted Allele Detail

Summary

• Symbol: Sertad1^tm1Srn
• Name: SERTA domain containing 1; targeted mutation 1, Manuel Serrano
• MGI ID: MGI:4437094
• Synonyms: Sei1-null
• Gene: Sertad1 Location: Chr7:27186378-27189741 bp, + strand Genetic Position: Chr7, 15.91 cM
• Alliance: Sertad1^tm1Srn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157231
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on ES cell extracts. (J:157231)

Generation of the Sertad1^tm1Srn allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sertad1^tm1Srn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sertad1 Mutation: 16 strains or lines available

References

• Original: J:157231 Fernandez-Marcos PJ, et al., Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. PLoS One. 2010;5(1):e8744
• All: 3 reference(s)