Fgf21^tm1Nit
Targeted Allele Detail

Summary

• Symbol: Fgf21^tm1Nit
• Name: fibroblast growth factor 21; targeted mutation 1, Nobuyuki Itoh
• MGI ID: MGI:4436721
• Gene: Fgf21 Location: Chr7:45263314-45264914 bp, - strand Genetic Position: Chr7, 29.38 cM, cytoband B2
• Alliance: Fgf21^tm1Nit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157334
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 1 and all of exons 2 and 3 were replaced with the IRES-LacZ-polyA/PGK-neo cassette. Absence of transcript in livers from homozygous mice was confirmed by RT-PCR. (J:157334)

Expression

In Mice Carrying this Mutation:	13 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf21 Mutation: 22 strains or lines available

References

• Original: J:157334 Hotta Y, et al., Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009 Oct;150(10):4625-33
• All: 37 reference(s)