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Targeted Allele Detail
Symbol: Fgf21tm1Nit
Name: fibroblast growth factor 21; targeted mutation 1, Nobuyuki Itoh
MGI ID: MGI:4436721
Gene: Fgf21  Location: Chr7:45613886-45615490 bp, - strand  Genetic Position: Chr7, 29.38 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:157334
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 1 and all of exons 2 and 3 were replaced with the IRES-LacZ-polyA/PGK-neo cassette. Absence of transcript in livers from homozygous mice was confirmed by RT-PCR. (J:157334)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf21 Mutation:  15 strains or lines available
Original:  J:157334 Hotta Y, et al., Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009 Oct;150(10):4625-33
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory