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Targeted Allele Detail
Symbol: Fgf21tm1Emf
Name: fibroblast growth factor 21; targeted mutation 1, Eleftheria Maratos-Flier
MGI ID: MGI:4436716
Gene: Fgf21  Location: Chr7:45613886-45615490 bp, - strand  Genetic Position: Chr7, 29.38 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:157309
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 1, all of exon 2 and the 5' region of exon 3 were replaced by a neomycin cassette by homologous recombination. Quantitative PCR confirmed the absence of product in the liver, perigonadal white adipose tissue and brown adipose tissue of ketogenetic diet fed homozygous mice . (J:157309)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf21 Mutation:  15 strains or lines available
Original:  J:157309 Badman MK, et al., Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009 Nov;150(11):4931-40
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory