Fkbp1a^{tm1a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Fkbp1a^{tm1a(EUCOMM)Hmgu}
• Name: FK506 binding protein 1a; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:4435583
• Gene: Fkbp1a Location: Chr2:151384403-151403611 bp, + strand Genetic Position: Chr2, 74.83 cM
• IMPC: Fkbp1a gene page

Mutation origin

• Mutant Cell Lines: HEPD0517_1_A04, HEPD0517_1_A06, HEPD0517_1_B04, HEPD0517_1_B05, HEPD0517_1_B06, HEPD0517_1_C04, HEPD0517_1_C05, HEPD0517_1_C06, HEPD0517_1_D04, HEPD0517_1_D05, HEPD0517_1_E04, HEPD0517_1_E05, HEPD0517_1_E06, HEPD0517_1_F04, HEPD0517_1_G05, HEPD0517_1_H05
• Germline Transmission: Unknown
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 151398851 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 151399696. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1a Mutation: 14 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)