Wdr45b^{tm1a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Wdr45b^{tm1a(EUCOMM)Hmgu}
• Name: WD repeat domain 45B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:4435538
• Gene: Wdr45b Location: Chr11:121218050-121245271 bp, - strand Genetic Position: Chr11, 85.24 cM
• Alliance: Wdr45b^{tm1a(EUCOMM)Hmgu} page
• IMPC: Wdr45b gene page

Mutation origin

• Mutant Cell Lines: HEPD0501_1_A11, HEPD0501_1_B11, HEPD0501_1_C10, HEPD0501_1_C11, HEPD0501_1_D11, HEPD0501_1_E10, HEPD0501_1_E11, HEPD0501_1_F10, HEPD0501_1_G12, HEPD0501_1_H10, HEPD0501_1_H11, HEPD0501_1_H12
• Germline Transmission: Earliest citation of germline transmission: J:298097
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 121229111 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 121229935. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr45b Mutation: 11 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 2 reference(s)