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Hprt1tm1a(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Hprt1tm1a(EUCOMM)Hmgu
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4435169
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm1a(EUCOMM)Hmgu page
IMPC: Hprt1 gene page
Mutation
origin
Mutant Cell Lines:  HEPD0543_8_A01, HEPD0543_8_A02, HEPD0543_8_A04, HEPD0543_8_A05, HEPD0543_8_A06, HEPD0543_8_B01, HEPD0543_8_B05, HEPD0543_8_B06, HEPD0543_8_C01, HEPD0543_8_C02, HEPD0543_8_C04, HEPD0543_8_C05, HEPD0543_8_C06, HEPD0543_8_D01, HEPD0543_8_D02, HEPD0543_8_D03, HEPD0543_8_D05, HEPD0543_8_D06, HEPD0543_8_E01, HEPD0543_8_E02, HEPD0543_8_E06, HEPD0543_8_F02, HEPD0543_8_F03, HEPD0543_8_F04, HEPD0543_8_F05, HEPD0543_8_F06, HEPD0543_8_G01, HEPD0543_8_G03, HEPD0543_8_G06, HEPD0543_8_H02, HEPD0543_8_H03, HEPD0543_8_H04, HEPD0543_8_H05, HEPD0543_8_H06
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 52090507 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 52091498. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Hprt1 Mutation:  1272 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory