About   Help   FAQ
Targeted Allele Detail
Symbol: Hprttm1a(EUCOMM)Hmgu
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4435169
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Mutant Cell Lines:  HEPD0543_8_A01, HEPD0543_8_A02, HEPD0543_8_A04, HEPD0543_8_A05, HEPD0543_8_A06, HEPD0543_8_B01, HEPD0543_8_B05, HEPD0543_8_B06, HEPD0543_8_C01, HEPD0543_8_C02, HEPD0543_8_C04, HEPD0543_8_C05, HEPD0543_8_C06, HEPD0543_8_D01, HEPD0543_8_D02, HEPD0543_8_D03, HEPD0543_8_D05, HEPD0543_8_D06, HEPD0543_8_E01, HEPD0543_8_E02, HEPD0543_8_E06, HEPD0543_8_F02, HEPD0543_8_F03, HEPD0543_8_F04, HEPD0543_8_F05, HEPD0543_8_F06, HEPD0543_8_G01, HEPD0543_8_G03, HEPD0543_8_G06, HEPD0543_8_H02, HEPD0543_8_H03, HEPD0543_8_H04, HEPD0543_8_H05, HEPD0543_8_H06 (Helmholtz Zentrum Muenchen GmbH)
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
Mutation detailsThe L1L2_gt2 cassette was inserted at position 53001630 of Chromosome X upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 53002621. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:157065)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  1254 strains or lines available
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.08
The Jackson Laboratory