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Targeted Allele Detail
Symbol: Rprd1btm1a(EUCOMM)Hmgu
Name: regulation of nuclear pre-mRNA domain containing 1B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4435125
Gene: Rprd1b  Location: Chr2:158028497-158132297 bp, + strand  Genetic Position: Chr2, 78.72 cM, cytoband H2
Mutant Cell Lines:  HEPD0555_3_A09, HEPD0555_3_A11, HEPD0555_3_B10, HEPD0555_3_B11, HEPD0555_3_B12, HEPD0555_3_C09, HEPD0555_3_C10, HEPD0555_3_C11, HEPD0555_3_D11, HEPD0555_3_D12, HEPD0555_3_E09, HEPD0555_3_E12, HEPD0555_3_F09, HEPD0555_3_G10, HEPD0555_3_G11, HEPD0555_3_G12, HEPD0555_3_H09, HEPD0555_3_H11 (Helmholtz Zentrum Muenchen GmbH)
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 158042916 of Chromosome 2 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 158043809. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:157065)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rprd1b Mutation:  10 strains or lines available
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory