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Targeted Allele Detail
Symbol: Abcd4tm1a(EUCOMM)Hmgu
Name: ATP-binding cassette, sub-family D (ALD), member 4; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4434636
Gene: Abcd4  Location: Chr12:84601869-84617485 bp, - strand  Genetic Position: Chr12, 39.3 cM
Mutant Cell Lines:  HEPD0530_5_A05, HEPD0530_5_A06, HEPD0530_5_A08, HEPD0530_5_B05, HEPD0530_5_B06, HEPD0530_5_B07, HEPD0530_5_B08, HEPD0530_5_C06, HEPD0530_5_C07, HEPD0530_5_D06, HEPD0530_5_D08, HEPD0530_5_E05, HEPD0530_5_F05, HEPD0530_5_G05, HEPD0530_5_G08, HEPD0530_5_H05, HEPD0530_5_H07
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Pgk_P
Mutation detailsThe L1L2_Pgk_P cassette was inserted at position 84614483 of Chromosome 12 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 84613632. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Abcd4 Mutation:  24 strains or lines available
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory