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Fbxo11tm2a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Fbxo11tm2a(EUCOMM)Wtsi
Name: F-box protein 11; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4434283
Gene: Fbxo11  Location: Chr17:87990859-88065291 bp, - strand  Genetic Position: Chr17, 57.87 cM
Mutation
origin
Mutant Cell Lines:  EPD0248_1_A01, EPD0248_1_C03, EPD0248_1_H03
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt1
 
Mutation detailsThe L1L2_gt1 cassette was inserted at position 88014972 of Chromosome 17 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 88014185. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 1 line available
Carrying any Fbxo11 Mutation:  33 strains or lines available
Notes
Cell line EPD0248_1_H03 was successfully used to make chimeric mice. Germline transmission was accomplished. J:220308
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory