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Urostm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Urostm1a(EUCOMM)Wtsi
Name: uroporphyrinogen III synthase; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4433834
Gene: Uros  Location: Chr7:133686243-133710072 bp, - strand  Genetic Position: Chr7, 77.26 cM
Mutation
origin
Mutant Cell Lines:  EPD0100_5_A01, EPD0100_5_A03, EPD0100_5_B02, EPD0100_5_C02, EPD0100_5_C03, EPD0100_5_C04, EPD0100_5_D04, EPD0100_5_E02, EPD0100_5_F01, EPD0100_5_F03, EPD0100_5_F04, EPD0100_5_G04, EPD0100_5_H02, EPD0100_5_H04 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 133701376 of Chromosome 7 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 133700558. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Uros Mutation:  11 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory