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Nxpe5tm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Nxpe5tm1a(EUCOMM)Wtsi
Name: neurexophilin and PC-esterase domain family, member 5; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4433447
Gene: Nxpe5  Location: Chr5:138225898-138253363 bp, + strand  Genetic Position: Chr5, 76.99 cM
Mutation
origin
Mutant Cell Lines:  EPD0327_3_A02, EPD0327_3_A03, EPD0327_3_C03, EPD0327_3_D01, EPD0327_3_D02, EPD0327_3_D03, EPD0327_3_D04, EPD0327_3_E02, EPD0327_3_F01, EPD0327_3_F04, EPD0327_3_G04 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 138240475 of Chromosome 5 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 138241397. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nxpe5 Mutation:  8 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory