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Cntfrtm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Cntfrtm1a(EUCOMM)Wtsi
Name: ciliary neurotrophic factor receptor; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4433013
Gene: Cntfr  Location: Chr4:41657498-41697089 bp, - strand  Genetic Position: Chr4, 21.81 cM
Mutation
origin
Mutant Cell Lines:  EPD0046_1_A07, EPD0046_1_A09, EPD0046_1_B08, EPD0046_1_C08, EPD0046_1_D08, EPD0046_1_E07, EPD0046_1_E09, EPD0046_1_F07, EPD0046_1_H08 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st0
 
Mutation detailsThe L1L2_st0 cassette was inserted at position 41675674 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 41674692. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cntfr Mutation:  37 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory