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Targeted Allele Detail
Symbol: Cdh1tm1a(EUCOMM)Wtsi
Name: cadherin 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432805
Gene: Cdh1  Location: Chr8:106603351-106670246 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Mutant Cell Lines:  EPD0036_1_A01, EPD0036_1_A03, EPD0036_1_B01, EPD0036_1_B02, EPD0036_1_B03, EPD0036_1_C01, EPD0036_1_C02, EPD0036_1_D01, EPD0036_1_D02, EPD0036_1_E02, EPD0036_1_F01, EPD0036_1_F02, EPD0036_1_F03, EPD0036_1_G01, EPD0036_1_H01, EPD0036_1_H02, EPD0036_1_H03 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st1
Mutation detailsThe L1L2_st1 cassette was inserted at position 106648575 of Chromosome 8 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 106649497. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  157 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory