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Hp1bp3tm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Hp1bp3tm1a(EUCOMM)Wtsi
Name: heterochromatin protein 1, binding protein 3; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432659
Gene: Hp1bp3  Location: Chr4:138216612-138244683 bp, + strand  Genetic Position: Chr4, 70.03 cM, cytoband D3
Mutation
origin
Mutant Cell Lines:  EPD0027_5_A11, EPD0027_5_C12, EPD0027_5_D12, EPD0027_5_E12, EPD0027_5_F11, EPD0027_5_G11, EPD0027_5_H11, EPD0027_5_H12
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 138229884 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 138230865. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534, J:223832, J:243926)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Hp1bp3 Mutation:  34 strains or lines available
Notes
Cell line EPD0027_5_F11 was successfully used to make chimeric mice. Germline transmission was accomplished. J:223832
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory