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Mecrtm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Mecrtm1a(EUCOMM)Wtsi
Name: mitochondrial trans-2-enoyl-CoA reductase; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432643
Gene: Mecr  Location: Chr4:131843470-131867786 bp, + strand  Genetic Position: Chr4, 64.52 cM
Mutation
origin
Mutant Cell Lines:  EPD0039_5_A01, EPD0039_5_B02, EPD0039_5_B03, EPD0039_5_C01, EPD0039_5_C02, EPD0039_5_D02, EPD0039_5_G01, EPD0039_5_H02, EPD0039_5_H03 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 131853477 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 131854053. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:155845, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mecr Mutation:  8 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory